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Filtered Search Results
Medchemexpress LLC Ag-494 | 133550-35-3 | MFCD00209863 | >98.0% | 280.28 g/mol | C16H12N2O3 | 5 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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AG-494 is a small-molecule inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase used in biochemical and cellular research to probe EGFR-mediated signaling pathways. The compound is supplied as a solid for laboratory use and is intended for research purposes only.
- Potent and selective EGFR tyrosine kinase inhibitor.
- Blocks EGFR autophosphorylation in biochemical and cell-based assays.
- Suitable for studying receptor-mediated signaling and inhibitor profiling.
- Available in small-scale quantities suitable for laboratory experiments.
- Provided as a solid with documented purity for research applications.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | 77521-29-0 | 99.8% | 186.17 g/mol | C7H10N2O4 | 10 MG
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Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (RS)-AMPA is a glutamate analogue that functions as a potent, selective agonist of AMPA-type ionotropic glutamate receptors. It is used in neuroscience research to activate AMPA receptors and study excitatory neurotransmission and receptor pharmacology. The compound is supplied as the free base at high purity suitable for laboratory experiments.
- Potent, selective AMPA receptor agonist.
- High purity suitable for research (99.8%).
- Supplied as free base form.
- Includes CAS number 77521-29-0 for unambiguous identification.
- Available in small quantities for lab-scale experiments (10 MG).
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC GSK2334470 | 1227911-45-6 | 99.8% | 462.59 g/mol | 100 MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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GSK2334470 is a highly specific and potent inhibitor of PDK1, exhibiting an IC50 of 10 nM. It demonstrates high selectivity, as it does not suppress the activity of 93 other protein kinases, including 13 AGC-kinases closely related to PDK1, even at concentrations 500-fold higher. In cellular studies, it effectively ablates T-loop residue phosphorylation and the activation of SGK isoforms and S6K1. In vivo, it has shown efficacy in delaying the development and inhibiting metastasis of melanoma.
- Highly specific and potent PDK1 inhibitor
- Demonstrates high selectivity, not affecting 93 other protein kinases
- Ablates T-loop residue phosphorylation and SGK/S6K1 activation
- Induces higher G0-G1 ratio in LAN-1-MK cells
- Inhibits melanoma development and metastasis in vivo
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Apexbio Technology LLC Gestodene 60282-87-3 50mg
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Gestodene (60282-87-3) is a small-molecule agonist targeting progesterone receptors It is designed to modulate the hypothalamic-pituitary-gonadal axis thereby regulating hormonal secretion and ovulatory processes Gestodene exerts its biological activity primarily through high-affinity binding and agonist activity on progesterone receptors leading to suppression of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) secretion inhibition of ovulation alteration of cervical mucus viscosity and modification of endometrial morphology Based on these pharmacological properties Gestodene holds research potential in reproductive biology endocrinology and contraceptive mechanism studies
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Medchemexpress LLC Nrf2-IN-1 | 1610022-76-8 | 99.9% | 383.87 | C21H22ClN3O2 | 1 ML
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Nrf2-IN-1 is a small-molecule inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) that targets the Keap1-Nrf2 pathway and is developed for preclinical research in acute myeloid leukemia (AML). It is available as a powder and as a ready-to-use 10 mM solution in DMSO, with reported activity inhibiting Nrf2 activation and inducing apoptosis in AML models.
- Inhibits Nrf2 activation in vitro.
- Reduces proliferation and induces apoptosis in AML cell lines.
- Supplied as powder and as a 10 mM solution in DMSO (1 mL), ready for use.
- High reported purity and characterized molecular properties.
- Soluble in DMSO; recommended storage conditions provided.
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Medchemexpress LLC PF-06263276 | 1421502-62-6 | 98.3% | 566.63 g/mol | C31H31FN8O2 | 50 MG
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PF-06263276 is a small-molecule pan-Janus kinase (pan-JAK) inhibitor supplied for preclinical and in vitro research. It reduces pSTAT3 and TYK2 pathway activation and is provided with analytical documentation for quality verification. Not for human or veterinary use.
- Inhibits JAK1, JAK2, JAK3, and TYK2 with reported low-nanomolar activity.
- Documented molecular weight 566.63 g/mol and chemical formula C31H31FN8O2.
- CAS number 1421502-62-6 for unambiguous identification.
- High purity reported (~98.3% by data sheet) with supporting analytical data.
- Available in small research quantities, including a 50 mg unit.
- Accompanied by certificate of analysis and safety data sheet for handling and compliance.
- Intended for in vitro and preclinical research use only.
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Apexbio Technology LLC Refametinib 923032-37-5 5mg
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Refametinib (CAS 923032-37-5) is an orally bioavailable selective allosteric inhibitor of mitogen-activated protein kinase kinases MEK1 and MEK2 It binds to an allosteric site distinct from the ATP-binding pocket thereby inhibiting MEK1 and MEK2 enzymatic activity (IC50 19 nM and 47 nM respectively) and blocking phosphorylation of ERK without interfering with ATP binding Refametinib demonstrates potent inhibition in human tumor cell lines with EC50 values ranging from 2 5 to 15 8 nM and suppresses proliferation in BRAF V600E-mutant lines (GI50 67 89 nM) It induces tumor growth delay and regression in xenograft models supporting its utility in cancer research
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Medchemexpress LLC Polydatin (Standard) | 27208-80-6 | 98.4% | 390.38 | 5 MG
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Polydatin (Standard) is the analytical standard of Polydatin, intended for research and analytical applications. Extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedy, it possesses anti-inflammatory activity in several experimental models and inhibits G6PD, inducing oxidative and ER stresses.
- Analytical standard for Polydatin
- Intended for research and analytical applications
- Extracted from the roots of Reynoutria japonica
- Possesses anti-inflammatory activity
- Inhibits G6PD, inducing oxidative and ER stresses
- Commonly used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
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Medchemexpress LLC Polydatin | 27208-80-6 | 99.50% | 390.38 | 1 ML
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Polydatin (Piceid), extracted from the roots of Reynoutria japonica, a widely used traditional Chinese remedy, possesses anti-inflammatory activity in several experimental models. It inhibits G6PD and induces oxidative and ER stresses. It is for research use only.
- Protects cerebral cells from ischemic damages via improvement of microcirculation and inhibition of platelet aggregation.
- Inhibits ICAM-1 expression in endothelial cells stimulated by lipopolysaccharide, and attenuates adhesion between white blood cells and endothelial cells.
- Inhibits cancer cell proliferation and cell cycle progression.
- Induces ER stress-driven cell death.
- Increases the activity of SOD and the heart rate, attenuates myocardial pathological damage, decreases MDA content, slightly increases arterial pressure and GSH-Px activity, reduces intervals of QRS, QT and ST, and lowers FFA content.
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Medchemexpress LLC Apiopaeonoside | 100291-86-9 | MFCD29049468 | 1 ML
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Apiopaeonoside is a natural product isolated from the root of Paeonia suffruticosa. This white to off-white solid has a molecular weight of 460.43 and a chemical formula of C20H28O12, with a purity of 99.81%. It is classified under phenols and is intended for research use only.
- Isolated from the root of Paeonia suffruticosa
- White to off-white solid
- Molecular weight of 460.43
- Chemical formula: C20H28O12
- Purity of 99.81%
- Soluble in DMSO at 100 mg/mL
- Storage as solid: 4°C, sealed, away from moisture and light
- Storage in solvent: -80°C for 6 months; -20°C for 1 month, sealed, away from moisture and light
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Medchemexpress LLC Methylophiopogonone B | 74805-89-3 | 1 MG
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Methylophiopogonone B is a homoisoflavonoidal compound isolated from Ophiopogonis Tuber. It demonstrates the ability to scavenge hydroxyl radicals (•OH) and hydrogen peroxide (H2O2) in vitro, making it suitable for various research applications.
- Homoisoflavonoidal compound
- Isolated from Ophiopogonis Tuber
- Capable of scavenging hydroxyl radicals and hydrogen peroxide in vitro
- Identified for use as laboratory chemical and in substance manufacturing
- Targets reactive oxygen species
- Involves pathways in immunology/inflammation, metabolic enzyme/protease, and NF-κB
- For research use only
- Stable under recommended storage conditions
- Appearance: solid, off-white to light yellow
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431517 IGDE PROTEASE 1KU
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000431524 BASEMENT MEMBRANE MA 10ML
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Apexbio Technology LLC RITA (NSC 652287) 213261-59-7 50mg
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RITA (NSC 652287 CAS 213261-59-7) is a synthetic thiophene-furan derivative identified for its potent antiproliferative activity particularly in renal carcinoma models Its precise molecular target remains unclear but pronounced differential cytotoxicity has been observed across tumor cell lines In vitro RITA exhibits an IC50 of 2 nM in A-498 and 20 nM in TK-10 cells with notable sensitivity compared to other lines (GI50 60 nM) In vivo subcutaneous administration in nude mice bearing A-498 xenografts resulted in complete tumor regression without detectable toxicity RITA is widely used for mechanistic studies of selective cytotoxicity and tumor biology
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Medchemexpress LLC AChE-IN-26 | 2977170-10-6 | C21H21BrN2O3 | 5 MG
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AChE-IN-26 (compound 4a) is an AChE (acetylcholinesterase) inhibitor with an IC50 value of 0.42 μM. It can be used for the research of Alzheimer's disease.
- AChE (acetylcholinesterase) inhibitor
- IC50 value of 0.42 μM
- Suitable for Alzheimer's disease research
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